| 16 Apr 2010 @ 11:20 | | Chicago Cubs |  | 7 | - | 2 |  | Houston Astros | Major League Baseball2010-04-16T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 17 Apr 2010 @ 10:05 | | Chicago Cubs | | 3 | - | 4 |  | Houston Astros | Major League Baseball2010-04-17T10:05:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 18 Apr 2010 @ 11:20 | | Chicago Cubs |  | 2 | OT | 3 |  | Houston Astros | Major League Baseball2010-04-18T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 4 Jun 2010 @ 17:05 | | Houston Astros | | 3 | - | 1 | | Chicago Cubs | Major League Baseball2010-06-04T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 5 Jun 2010 @ 16:05 | | Houston Astros |  | 5 | - | 8 | | Chicago Cubs | Major League Baseball2010-06-05T16:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 6 Jun 2010 @ 11:05 | | Houston Astros |  | 6 | - | 3 |  | Chicago Cubs | Major League Baseball2010-06-06T11:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 19 Jul 2010 @ 17:05 | | Chicago Cubs | | 5 | - | 11 | | Houston Astros | Major League Baseball2010-07-19T17:05:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 20 Jul 2010 @ 17:05 | | Chicago Cubs | | 14 | - | 7 | | Houston Astros | Major League Baseball2010-07-20T17:05:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 21 Jul 2010 @ 11:20 | | Chicago Cubs | | 3 | - | 4 | | Houston Astros | Major League Baseball2010-07-21T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 26 Jul 2010 @ 17:05 | | Houston Astros | | 2 | - | 5 | | Chicago Cubs | Major League Baseball2010-07-26T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 27 Jul 2010 @ 17:05 | | Houston Astros | | 6 | - | 1 |  | Chicago Cubs | Major League Baseball2010-07-27T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 28 Jul 2010 @ 11:05 | | Houston Astros | | 8 | - | 1 | | Chicago Cubs | Major League Baseball2010-07-28T11:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 6 Sep 2010 @ 11:20 | | Chicago Cubs | | 5 | - | 4 | | Houston Astros | Major League Baseball2010-09-06T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 7 Sep 2010 @ 17:05 | | Chicago Cubs | | 3 | - | 7 | | Houston Astros | Major League Baseball2010-09-07T17:05:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 8 Sep 2010 @ 17:05 | | Chicago Cubs | | 0 | - | 4 | | Houston Astros | Major League Baseball2010-09-08T17:05:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 1 Oct 2010 @ 17:05 | | Houston Astros | | 0 | - | 2 | | Chicago Cubs | Major League Baseball2010-10-01T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 2 Oct 2010 @ 16:05 | | Houston Astros | | 3 | - | 8 | | Chicago Cubs | Major League Baseball2010-10-02T16:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 3 Oct 2010 @ 11:05 | | Houston Astros | | 4 | - | 0 | | Chicago Cubs | Major League Baseball2010-10-03T11:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
|
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| 11 Apr 2011 @ 17:05 | | Houston Astros | | Vs | | Chicago Cubs | Major League Baseball2011-04-11T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 12 Apr 2011 @ 17:05 | | Houston Astros | | Vs |  | Chicago Cubs | Major League Baseball2011-04-12T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 13 Apr 2011 @ 17:05 | | Houston Astros | | Vs | | Chicago Cubs | Major League Baseball2011-04-13T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 30 May 2011 @ 11:20 | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-05-30T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 31 May 2011 @ 17:05 | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-05-31T17:05:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 1 Jun 2011 @ 11:20 | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-06-01T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 22 Jul 2011 @ 11:20 | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-07-22T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 23 Jul 2011 @ 10:05 | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-07-23T10:05:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 24 Jul 2011 @ 11:20 | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-07-24T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 15 Aug 2011 @ 17:05 | | Houston Astros | | Vs | | Chicago Cubs | Major League Baseball2011-08-15T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 16 Aug 2011 @ 17:05 | | Houston Astros | | Vs | | Chicago Cubs | Major League Baseball2011-08-16T17:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 17 Aug 2011 @ 11:05 | | Houston Astros | | Vs | | Chicago Cubs | Major League Baseball2011-08-17T11:05:00-07:00Houston Astros v Chicago Cubs | Minute Maid Park, Houston, TX, USA |
| 16 Sep 2011 @ 11:20 | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-09-16T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 17 Sep 2011 TBA | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-09-17T09:34:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
| 18 Sep 2011 @ 11:20 | | Chicago Cubs | | Vs | | Houston Astros | Major League Baseball2011-09-18T11:20:00-07:00Chicago Cubs v Houston Astros | Wrigley Field, Chicago, IL, USA |
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